REVIEW Role of the Kupffer Cell in Mediating Hepatic Toxicity and Carcinogenesis
نویسندگان
چکیده
*AstraZeneca, Safety Assessment Alderley Park, Macclesfield, Cheshire, SK10 4TG United Kingdom; †Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan MI 48824; ‡Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado CO 80262; §Department of Environmental Sciences and Engineering, University of North Carolina School of Public Health, Chapel Hill, North Carolina IN 46202; and Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana NC 27599-7431
منابع مشابه
Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis.
Kupffer cells are resident macrophages of the liver and play an important role in its normal physiology and homeostasis as well as participating in the acute and chronic responses of the liver to toxic compounds. Activation of Kupffer cells directly or indirectly by toxic agents results in the release of an array of inflammatory mediators, growth factors, and reactive oxygen species. This activ...
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Chronic inflammation drives liver cancer pathogenesis, invasion, and metastasis. Liver Kupffer cells have crucial roles in mediating the inflammatory processes that promote liver cancer, but the mechanistic basis for their contributions are not fully understood. Here we show that expression of the proinflammatory myeloid cell surface receptor TREM-1 expressed by Kupffer cells is a crucial facto...
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BACKGROUND It has been proposed that PPARalpha agonists stimulate Kupffer cells in rodents which in turn, release mitogenic factors leading to hepatic hyperplasia, and eventually cancer. However, Kupffer cells do not express PPARalpha receptors, and PPARalpha agonists stimulate hepatocellular proliferation in both TNFalpha- and TNFalpha receptor-null mice, casting doubt on the involvement of Ku...
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تاریخ انتشار 2006